HIGH FRUCTOSE CORN SYRUP AND OBESITY

Gabe Mirkin, M.D.

Several recent studies have shown that fructose is processed differently in the body than the far more common sugar, glucose (3,4). Glucose causes the pancreas to release insulin which drives sugar from the bloodstream into cells. Glucose causes fat cells to release leptin that makes you feel full so you eat less. Glucose prevents the stomach from releasing ghrelin that makes you hungry. On the other hand, fructose does not cause fat cells to release leptin and does not suppress ghrelin. This means that fructose increases hunger to make you eat more. Furthermore, the liver converts fructose far more readily to a body fat called triglyceride, than it does with glucose. High triglyceride levels raise blood levels of the bad LDL cholesterol and lower blood levels of the good HDL cholesterol, which increases heart attack risk.

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